diff --git a/src/core/hle/service/acc/acc.cpp b/src/core/hle/service/acc/acc.cpp
index e61748ca3..cf065c2e0 100644
--- a/src/core/hle/service/acc/acc.cpp
+++ b/src/core/hle/service/acc/acc.cpp
@@ -2,9 +2,13 @@
 // Licensed under GPLv2 or any later version
 // Refer to the license.txt file included.
 
+#include <algorithm>
 #include <array>
+#include "common/common_paths.h"
 #include "common/common_types.h"
+#include "common/file_util.h"
 #include "common/logging/log.h"
+#include "common/string_util.h"
 #include "common/swap.h"
 #include "core/core_timing.h"
 #include "core/hle/ipc_helpers.h"
@@ -16,6 +20,9 @@
 #include "core/hle/service/acc/profile_manager.h"
 
 namespace Service::Account {
+
+constexpr u32 MAX_JPEG_IMAGE_SIZE = 0x20000;
+
 // TODO: RE this structure
 struct UserData {
     INSERT_PADDING_WORDS(1);
@@ -27,6 +34,11 @@ struct UserData {
 };
 static_assert(sizeof(UserData) == 0x80, "UserData structure has incorrect size");
 
+static std::string GetImagePath(UUID uuid) {
+    return FileUtil::GetUserPath(FileUtil::UserPath::NANDDir) +
+           "/system/save/8000000000000010/su/avators/" + uuid.FormatSwitch() + ".jpg";
+}
+
 class IProfile final : public ServiceFramework<IProfile> {
 public:
     explicit IProfile(UUID user_id, ProfileManager& profile_manager)
@@ -73,11 +85,11 @@ private:
     }
 
     void LoadImage(Kernel::HLERequestContext& ctx) {
-        LOG_WARNING(Service_ACC, "(STUBBED) called");
+        LOG_DEBUG(Service_ACC, "called");
         // smallest jpeg https://github.com/mathiasbynens/small/blob/master/jpeg.jpg
-        // TODO(mailwl): load actual profile image from disk, width 256px, max size 0x20000
-        constexpr u32 jpeg_size = 107;
-        static constexpr std::array<u8, jpeg_size> jpeg{
+        // used as a backup should the one on disk not exist
+        constexpr u32 backup_jpeg_size = 107;
+        static constexpr std::array<u8, backup_jpeg_size> backup_jpeg{
             0xff, 0xd8, 0xff, 0xdb, 0x00, 0x43, 0x00, 0x03, 0x02, 0x02, 0x02, 0x02, 0x02, 0x03,
             0x02, 0x02, 0x02, 0x03, 0x03, 0x03, 0x03, 0x04, 0x06, 0x04, 0x04, 0x04, 0x04, 0x04,
             0x08, 0x06, 0x06, 0x05, 0x06, 0x09, 0x08, 0x0a, 0x0a, 0x09, 0x08, 0x09, 0x09, 0x0a,
@@ -87,18 +99,42 @@ private:
             0xff, 0xcc, 0x00, 0x06, 0x00, 0x10, 0x10, 0x05, 0xff, 0xda, 0x00, 0x08, 0x01, 0x01,
             0x00, 0x00, 0x3f, 0x00, 0xd2, 0xcf, 0x20, 0xff, 0xd9,
         };
-        ctx.WriteBuffer(jpeg);
+
         IPC::ResponseBuilder rb{ctx, 3};
         rb.Push(RESULT_SUCCESS);
-        rb.Push<u32>(jpeg_size);
+
+        const FileUtil::IOFile image(GetImagePath(user_id), "rb");
+
+        if (!image.IsOpen()) {
+            LOG_WARNING(Service_ACC,
+                        "Failed to load user provided image! Falling back to built-in backup...");
+            ctx.WriteBuffer(backup_jpeg);
+            rb.Push<u32>(backup_jpeg_size);
+        } else {
+            const auto size = std::min<u32>(image.GetSize(), MAX_JPEG_IMAGE_SIZE);
+            std::vector<u8> buffer(size);
+            image.ReadBytes(buffer.data(), buffer.size());
+
+            ctx.WriteBuffer(buffer.data(), buffer.size());
+            rb.Push<u32>(buffer.size());
+        }
     }
 
     void GetImageSize(Kernel::HLERequestContext& ctx) {
-        LOG_WARNING(Service_ACC, "(STUBBED) called");
-        constexpr u32 jpeg_size = 107;
+        LOG_DEBUG(Service_ACC, "called");
+        constexpr u32 backup_jpeg_size = 107;
         IPC::ResponseBuilder rb{ctx, 3};
         rb.Push(RESULT_SUCCESS);
-        rb.Push<u32>(jpeg_size);
+
+        const FileUtil::IOFile image(GetImagePath(user_id), "rb");
+
+        if (!image.IsOpen()) {
+            LOG_WARNING(Service_ACC,
+                        "Failed to load user provided image! Falling back to built-in backup...");
+            rb.Push<u32>(backup_jpeg_size);
+        } else {
+            rb.Push<u32>(std::min<u32>(image.GetSize(), MAX_JPEG_IMAGE_SIZE));
+        }
     }
 
     const ProfileManager& profile_manager;
diff --git a/src/core/hle/service/acc/profile_manager.cpp b/src/core/hle/service/acc/profile_manager.cpp
index bcb3475db..06f7d1b15 100644
--- a/src/core/hle/service/acc/profile_manager.cpp
+++ b/src/core/hle/service/acc/profile_manager.cpp
@@ -4,32 +4,57 @@
 
 #include <random>
 #include <boost/optional.hpp>
+#include "common/file_util.h"
 #include "core/hle/service/acc/profile_manager.h"
 #include "core/settings.h"
 
 namespace Service::Account {
+
+struct UserRaw {
+    UUID uuid;
+    UUID uuid2;
+    u64 timestamp;
+    ProfileUsername username;
+    INSERT_PADDING_BYTES(0x80);
+};
+static_assert(sizeof(UserRaw) == 0xC8, "UserRaw has incorrect size.");
+
+struct ProfileDataRaw {
+    INSERT_PADDING_BYTES(0x10);
+    std::array<UserRaw, MAX_USERS> users;
+};
+static_assert(sizeof(ProfileDataRaw) == 0x650, "ProfileDataRaw has incorrect size.");
+
 // TODO(ogniK): Get actual error codes
 constexpr ResultCode ERROR_TOO_MANY_USERS(ErrorModule::Account, -1);
 constexpr ResultCode ERROR_USER_ALREADY_EXISTS(ErrorModule::Account, -2);
 constexpr ResultCode ERROR_ARGUMENT_IS_NULL(ErrorModule::Account, 20);
 
-const UUID& UUID::Generate() {
+constexpr char ACC_SAVE_AVATORS_BASE_PATH[] = "/system/save/8000000000000010/su/avators/";
+
+UUID UUID::Generate() {
     std::random_device device;
     std::mt19937 gen(device());
     std::uniform_int_distribution<u64> distribution(1, std::numeric_limits<u64>::max());
-    uuid[0] = distribution(gen);
-    uuid[1] = distribution(gen);
-    return *this;
+    return UUID{distribution(gen), distribution(gen)};
 }
 
 ProfileManager::ProfileManager() {
-    // TODO(ogniK): Create the default user we have for now until loading/saving users is added
-    auto user_uuid = UUID{1, 0};
-    ASSERT(CreateNewUser(user_uuid, Settings::values.username).IsSuccess());
-    OpenUser(user_uuid);
+    ParseUserSaveFile();
+
+    if (user_count == 0)
+        CreateNewUser(UUID::Generate(), "yuzu");
+
+    auto current = std::clamp<int>(Settings::values.current_user, 0, MAX_USERS - 1);
+    if (UserExistsIndex(current))
+        current = 0;
+
+    OpenUser(*GetUser(current));
 }
 
-ProfileManager::~ProfileManager() = default;
+ProfileManager::~ProfileManager() {
+    WriteUserSaveFile();
+}
 
 /// After a users creation it needs to be "registered" to the system. AddToProfiles handles the
 /// internal management of the users profiles
@@ -101,6 +126,12 @@ ResultCode ProfileManager::CreateNewUser(UUID uuid, const std::string& username)
     return CreateNewUser(uuid, username_output);
 }
 
+boost::optional<UUID> ProfileManager::GetUser(std::size_t index) const {
+    if (index >= MAX_USERS)
+        return boost::none;
+    return profiles[index].user_uuid;
+}
+
 /// Returns a users profile index based on their user id.
 boost::optional<std::size_t> ProfileManager::GetUserIndex(const UUID& uuid) const {
     if (!uuid) {
@@ -164,6 +195,12 @@ bool ProfileManager::UserExists(UUID uuid) const {
     return (GetUserIndex(uuid) != boost::none);
 }
 
+bool ProfileManager::UserExistsIndex(std::size_t index) const {
+    if (index >= MAX_USERS)
+        return false;
+    return profiles[index].user_uuid.uuid != INVALID_UUID;
+}
+
 /// Opens a specific user
 void ProfileManager::OpenUser(UUID uuid) {
     auto idx = GetUserIndex(uuid);
@@ -239,4 +276,96 @@ bool ProfileManager::CanSystemRegisterUser() const {
     // emulate qlaunch. Update this to dynamically change.
 }
 
+bool ProfileManager::RemoveUser(UUID uuid) {
+    auto index = GetUserIndex(uuid);
+    if (index == boost::none) {
+        return false;
+    }
+
+    profiles[*index] = ProfileInfo{};
+    std::stable_partition(profiles.begin(), profiles.end(),
+                          [](const ProfileInfo& profile) { return profile.user_uuid; });
+    return true;
+}
+
+bool ProfileManager::SetProfileBase(UUID uuid, const ProfileBase& profile_new) {
+    auto index = GetUserIndex(uuid);
+    if (profile_new.user_uuid == UUID(INVALID_UUID) || index == boost::none) {
+        return false;
+    }
+
+    auto& profile = profiles[*index];
+    profile.user_uuid = profile_new.user_uuid;
+    profile.username = profile_new.username;
+    profile.creation_time = profile_new.timestamp;
+
+    return true;
+}
+
+void ProfileManager::ParseUserSaveFile() {
+    FileUtil::IOFile save(FileUtil::GetUserPath(FileUtil::UserPath::NANDDir) +
+                              ACC_SAVE_AVATORS_BASE_PATH + "profiles.dat",
+                          "rb");
+
+    if (!save.IsOpen()) {
+        LOG_WARNING(Service_ACC, "Failed to load profile data from save data... Generating new "
+                                 "user 'yuzu' with random UUID.");
+        return;
+    }
+
+    ProfileDataRaw data;
+    if (save.ReadBytes(&data, sizeof(ProfileDataRaw)) != sizeof(ProfileDataRaw)) {
+        LOG_WARNING(Service_ACC, "profiles.dat is smaller than expected... Generating new user "
+                                 "'yuzu' with random UUID.");
+        return;
+    }
+
+    for (std::size_t i = 0; i < MAX_USERS; ++i) {
+        const auto& user = data.users[i];
+
+        if (user.uuid != UUID(INVALID_UUID))
+            AddUser({user.uuid, user.username, user.timestamp, {}, false});
+    }
+
+    std::stable_partition(profiles.begin(), profiles.end(),
+                          [](const ProfileInfo& profile) { return profile.user_uuid; });
+}
+
+void ProfileManager::WriteUserSaveFile() {
+    ProfileDataRaw raw{};
+
+    for (std::size_t i = 0; i < MAX_USERS; ++i) {
+        raw.users[i].username = profiles[i].username;
+        raw.users[i].uuid2 = profiles[i].user_uuid;
+        raw.users[i].uuid = profiles[i].user_uuid;
+        raw.users[i].timestamp = profiles[i].creation_time;
+    }
+
+    const auto raw_path =
+        FileUtil::GetUserPath(FileUtil::UserPath::NANDDir) + "/system/save/8000000000000010";
+    if (FileUtil::Exists(raw_path) && !FileUtil::IsDirectory(raw_path))
+        FileUtil::Delete(raw_path);
+
+    const auto path = FileUtil::GetUserPath(FileUtil::UserPath::NANDDir) +
+                      ACC_SAVE_AVATORS_BASE_PATH + "profiles.dat";
+
+    if (!FileUtil::CreateFullPath(path)) {
+        LOG_WARNING(Service_ACC, "Failed to create full path of profiles.dat. Create the directory "
+                                 "nand/system/save/8000000000000010/su/avators to mitigate this "
+                                 "issue.");
+        return;
+    }
+
+    FileUtil::IOFile save(path, "wb");
+
+    if (!save.IsOpen()) {
+        LOG_WARNING(Service_ACC, "Failed to write save data to file... No changes to user data "
+                                 "made in current session will be saved.");
+        return;
+    }
+
+    save.Resize(sizeof(ProfileDataRaw));
+    save.WriteBytes(&raw, sizeof(ProfileDataRaw));
+}
+
 }; // namespace Service::Account
diff --git a/src/core/hle/service/acc/profile_manager.h b/src/core/hle/service/acc/profile_manager.h
index bffd4cf4d..235208d56 100644
--- a/src/core/hle/service/acc/profile_manager.h
+++ b/src/core/hle/service/acc/profile_manager.h
@@ -36,7 +36,7 @@ struct UUID {
     }
 
     // TODO(ogniK): Properly generate uuids based on RFC-4122
-    const UUID& Generate();
+    static UUID Generate();
 
     // Set the UUID to {0,0} to be considered an invalid user
     void Invalidate() {
@@ -45,6 +45,15 @@ struct UUID {
     std::string Format() const {
         return fmt::format("0x{:016X}{:016X}", uuid[1], uuid[0]);
     }
+
+    std::string FormatSwitch() const {
+        std::array<u8, 16> s{};
+        std::memcpy(s.data(), uuid.data(), sizeof(u128));
+        return fmt::format("{:02x}{:02x}{:02x}{:02x}-{:02x}{:02x}-{:02x}{:02x}-{:02x}{:02x}-{:02x}{"
+                           ":02x}{:02x}{:02x}{:02x}{:02x}",
+                           s[0], s[1], s[2], s[3], s[4], s[5], s[6], s[7], s[8], s[9], s[10], s[11],
+                           s[12], s[13], s[14], s[15]);
+    }
 };
 static_assert(sizeof(UUID) == 16, "UUID is an invalid size!");
 
@@ -81,12 +90,13 @@ static_assert(sizeof(ProfileBase) == 0x38, "ProfileBase is an invalid size");
 /// objects
 class ProfileManager {
 public:
-    ProfileManager(); // TODO(ogniK): Load from system save
+    ProfileManager();
     ~ProfileManager();
 
     ResultCode AddUser(const ProfileInfo& user);
     ResultCode CreateNewUser(UUID uuid, const ProfileUsername& username);
     ResultCode CreateNewUser(UUID uuid, const std::string& username);
+    boost::optional<UUID> GetUser(std::size_t index) const;
     boost::optional<std::size_t> GetUserIndex(const UUID& uuid) const;
     boost::optional<std::size_t> GetUserIndex(const ProfileInfo& user) const;
     bool GetProfileBase(boost::optional<std::size_t> index, ProfileBase& profile) const;
@@ -100,6 +110,7 @@ public:
     std::size_t GetUserCount() const;
     std::size_t GetOpenUserCount() const;
     bool UserExists(UUID uuid) const;
+    bool UserExistsIndex(std::size_t index) const;
     void OpenUser(UUID uuid);
     void CloseUser(UUID uuid);
     UserIDArray GetOpenUsers() const;
@@ -108,7 +119,13 @@ public:
 
     bool CanSystemRegisterUser() const;
 
+    bool RemoveUser(UUID uuid);
+    bool SetProfileBase(UUID uuid, const ProfileBase& profile);
+
 private:
+    void ParseUserSaveFile();
+    void WriteUserSaveFile();
+
     std::array<ProfileInfo, MAX_USERS> profiles{};
     std::size_t user_count = 0;
     boost::optional<std::size_t> AddToProfiles(const ProfileInfo& profile);
diff --git a/src/core/hle/service/am/am.cpp b/src/core/hle/service/am/am.cpp
index ecf72ae24..4ed66d817 100644
--- a/src/core/hle/service/am/am.cpp
+++ b/src/core/hle/service/am/am.cpp
@@ -4,11 +4,13 @@
 
 #include <array>
 #include <cinttypes>
+#include <cstring>
 #include <stack>
 #include "core/core.h"
 #include "core/hle/ipc_helpers.h"
 #include "core/hle/kernel/event.h"
 #include "core/hle/kernel/process.h"
+#include "core/hle/service/acc/profile_manager.h"
 #include "core/hle/service/am/am.h"
 #include "core/hle/service/am/applet_ae.h"
 #include "core/hle/service/am/applet_oe.h"
@@ -26,6 +28,16 @@
 
 namespace Service::AM {
 
+constexpr u32 POP_LAUNCH_PARAMETER_MAGIC = 0xC79497CA;
+
+struct LaunchParameters {
+    u32_le magic;
+    u32_le is_account_selected;
+    u128 current_user;
+    INSERT_PADDING_BYTES(0x70);
+};
+static_assert(sizeof(LaunchParameters) == 0x88);
+
 IWindowController::IWindowController() : ServiceFramework("IWindowController") {
     // clang-format off
     static const FunctionInfo functions[] = {
@@ -724,20 +736,23 @@ void IApplicationFunctions::EndBlockingHomeButton(Kernel::HLERequestContext& ctx
 }
 
 void IApplicationFunctions::PopLaunchParameter(Kernel::HLERequestContext& ctx) {
-    constexpr std::array<u8, 0x88> data{{
-        0xca, 0x97, 0x94, 0xc7, // Magic
-        1,    0,    0,    0,    // IsAccountSelected (bool)
-        1,    0,    0,    0,    // User Id (word 0)
-        0,    0,    0,    0,    // User Id (word 1)
-        0,    0,    0,    0,    // User Id (word 2)
-        0,    0,    0,    0     // User Id (word 3)
-    }};
+    LaunchParameters params{};
 
-    std::vector<u8> buffer(data.begin(), data.end());
+    params.magic = POP_LAUNCH_PARAMETER_MAGIC;
+    params.is_account_selected = 1;
+
+    Account::ProfileManager profile_manager{};
+    const auto uuid = profile_manager.GetUser(Settings::values.current_user);
+    ASSERT(uuid != boost::none);
+    params.current_user = uuid->uuid;
 
     IPC::ResponseBuilder rb{ctx, 2, 0, 1};
 
     rb.Push(RESULT_SUCCESS);
+
+    std::vector<u8> buffer(sizeof(LaunchParameters));
+    std::memcpy(buffer.data(), &params, buffer.size());
+
     rb.PushIpcInterface<AM::IStorage>(buffer);
 
     LOG_DEBUG(Service_AM, "called");
diff --git a/src/core/settings.h b/src/core/settings.h
index ca80718e2..b5aeff29b 100644
--- a/src/core/settings.h
+++ b/src/core/settings.h
@@ -114,7 +114,7 @@ struct Values {
     // System
     bool use_docked_mode;
     bool enable_nfc;
-    std::string username;
+    int current_user;
     int language_index;
 
     // Controls
diff --git a/src/yuzu/configuration/config.cpp b/src/yuzu/configuration/config.cpp
index d029590ff..1fe9a7edd 100644
--- a/src/yuzu/configuration/config.cpp
+++ b/src/yuzu/configuration/config.cpp
@@ -4,6 +4,7 @@
 
 #include <QSettings>
 #include "common/file_util.h"
+#include "core/hle/service/acc/profile_manager.h"
 #include "input_common/main.h"
 #include "yuzu/configuration/config.h"
 #include "yuzu/ui_settings.h"
@@ -123,7 +124,10 @@ void Config::ReadValues() {
     qt_config->beginGroup("System");
     Settings::values.use_docked_mode = qt_config->value("use_docked_mode", false).toBool();
     Settings::values.enable_nfc = qt_config->value("enable_nfc", true).toBool();
-    Settings::values.username = qt_config->value("username", "yuzu").toString().toStdString();
+
+    Settings::values.current_user = std::clamp<int>(qt_config->value("current_user", 0).toInt(), 0,
+                                                    Service::Account::MAX_USERS - 1);
+
     Settings::values.language_index = qt_config->value("language_index", 1).toInt();
     qt_config->endGroup();
 
@@ -260,7 +264,8 @@ void Config::SaveValues() {
     qt_config->beginGroup("System");
     qt_config->setValue("use_docked_mode", Settings::values.use_docked_mode);
     qt_config->setValue("enable_nfc", Settings::values.enable_nfc);
-    qt_config->setValue("username", QString::fromStdString(Settings::values.username));
+    qt_config->setValue("current_user", Settings::values.current_user);
+
     qt_config->setValue("language_index", Settings::values.language_index);
     qt_config->endGroup();
 
diff --git a/src/yuzu/configuration/configure_system.cpp b/src/yuzu/configuration/configure_system.cpp
index e9ed9c38f..83cc49dfc 100644
--- a/src/yuzu/configuration/configure_system.cpp
+++ b/src/yuzu/configuration/configure_system.cpp
@@ -2,13 +2,30 @@
 // Licensed under GPLv2 or any later version
 // Refer to the license.txt file included.
 
+#include <algorithm>
+#include <QFileDialog>
+#include <QGraphicsItem>
+#include <QGraphicsScene>
+#include <QInputDialog>
 #include <QMessageBox>
+#include <QStandardItemModel>
+#include <QTreeView>
+#include <QVBoxLayout>
+#include "common/common_paths.h"
+#include "common/logging/backend.h"
+#include "common/string_util.h"
 #include "core/core.h"
+#include "core/hle/service/acc/profile_manager.h"
 #include "core/settings.h"
 #include "ui_configure_system.h"
 #include "yuzu/configuration/configure_system.h"
 #include "yuzu/main.h"
 
+static std::string GetImagePath(Service::Account::UUID uuid) {
+    return FileUtil::GetUserPath(FileUtil::UserPath::NANDDir) +
+           "/system/save/8000000000000010/su/avators/" + uuid.FormatSwitch() + ".jpg";
+}
+
 static const std::array<int, 12> days_in_month = {{
     31,
     29,
@@ -24,7 +41,20 @@ static const std::array<int, 12> days_in_month = {{
     31,
 }};
 
-ConfigureSystem::ConfigureSystem(QWidget* parent) : QWidget(parent), ui(new Ui::ConfigureSystem) {
+// Same backup JPEG used by acc IProfile::GetImage if no jpeg found
+static constexpr std::array<u8, 107> backup_jpeg{
+    0xff, 0xd8, 0xff, 0xdb, 0x00, 0x43, 0x00, 0x03, 0x02, 0x02, 0x02, 0x02, 0x02, 0x03, 0x02, 0x02,
+    0x02, 0x03, 0x03, 0x03, 0x03, 0x04, 0x06, 0x04, 0x04, 0x04, 0x04, 0x04, 0x08, 0x06, 0x06, 0x05,
+    0x06, 0x09, 0x08, 0x0a, 0x0a, 0x09, 0x08, 0x09, 0x09, 0x0a, 0x0c, 0x0f, 0x0c, 0x0a, 0x0b, 0x0e,
+    0x0b, 0x09, 0x09, 0x0d, 0x11, 0x0d, 0x0e, 0x0f, 0x10, 0x10, 0x11, 0x10, 0x0a, 0x0c, 0x12, 0x13,
+    0x12, 0x10, 0x13, 0x0f, 0x10, 0x10, 0x10, 0xff, 0xc9, 0x00, 0x0b, 0x08, 0x00, 0x01, 0x00, 0x01,
+    0x01, 0x01, 0x11, 0x00, 0xff, 0xcc, 0x00, 0x06, 0x00, 0x10, 0x10, 0x05, 0xff, 0xda, 0x00, 0x08,
+    0x01, 0x01, 0x00, 0x00, 0x3f, 0x00, 0xd2, 0xcf, 0x20, 0xff, 0xd9,
+};
+
+ConfigureSystem::ConfigureSystem(QWidget* parent)
+    : QWidget(parent), ui(new Ui::ConfigureSystem),
+      profile_manager(std::make_unique<Service::Account::ProfileManager>()) {
     ui->setupUi(this);
     connect(ui->combo_birthmonth,
             static_cast<void (QComboBox::*)(int)>(&QComboBox::currentIndexChanged), this,
@@ -32,6 +62,45 @@ ConfigureSystem::ConfigureSystem(QWidget* parent) : QWidget(parent), ui(new Ui::
     connect(ui->button_regenerate_console_id, &QPushButton::clicked, this,
             &ConfigureSystem::refreshConsoleID);
 
+    layout = new QVBoxLayout;
+    tree_view = new QTreeView;
+    item_model = new QStandardItemModel(tree_view);
+    tree_view->setModel(item_model);
+
+    tree_view->setAlternatingRowColors(true);
+    tree_view->setSelectionMode(QHeaderView::SingleSelection);
+    tree_view->setSelectionBehavior(QHeaderView::SelectRows);
+    tree_view->setVerticalScrollMode(QHeaderView::ScrollPerPixel);
+    tree_view->setHorizontalScrollMode(QHeaderView::ScrollPerPixel);
+    tree_view->setSortingEnabled(true);
+    tree_view->setEditTriggers(QHeaderView::NoEditTriggers);
+    tree_view->setUniformRowHeights(true);
+    tree_view->setIconSize({64, 64});
+    tree_view->setContextMenuPolicy(Qt::NoContextMenu);
+
+    item_model->insertColumns(0, 1);
+    item_model->setHeaderData(0, Qt::Horizontal, "Users");
+
+    // We must register all custom types with the Qt Automoc system so that we are able to use it
+    // with signals/slots. In this case, QList falls under the umbrells of custom types.
+    qRegisterMetaType<QList<QStandardItem*>>("QList<QStandardItem*>");
+
+    layout->setContentsMargins(0, 0, 0, 0);
+    layout->setSpacing(0);
+    layout->addWidget(tree_view);
+
+    ui->scrollArea->setLayout(layout);
+
+    connect(tree_view, &QTreeView::clicked, this, &ConfigureSystem::SelectUser);
+
+    connect(ui->pm_add, &QPushButton::pressed, this, &ConfigureSystem::AddUser);
+    connect(ui->pm_rename, &QPushButton::pressed, this, &ConfigureSystem::RenameUser);
+    connect(ui->pm_remove, &QPushButton::pressed, this, &ConfigureSystem::DeleteUser);
+    connect(ui->pm_set_image, &QPushButton::pressed, this, &ConfigureSystem::SetUserImage);
+
+    scene = new QGraphicsScene;
+    ui->current_user_icon->setScene(scene);
+
     this->setConfiguration();
 }
 
@@ -39,16 +108,74 @@ ConfigureSystem::~ConfigureSystem() = default;
 
 void ConfigureSystem::setConfiguration() {
     enabled = !Core::System::GetInstance().IsPoweredOn();
-    ui->edit_username->setText(QString::fromStdString(Settings::values.username));
+
     ui->combo_language->setCurrentIndex(Settings::values.language_index);
+
+    item_model->removeRows(0, item_model->rowCount());
+    list_items.clear();
+
+    PopulateUserList();
+    UpdateCurrentUser();
+}
+
+static QPixmap GetIcon(Service::Account::UUID uuid) {
+    const auto icon_url = QString::fromStdString(GetImagePath(uuid));
+    QPixmap icon{icon_url};
+
+    if (!icon) {
+        icon.fill(Qt::black);
+        icon.loadFromData(backup_jpeg.data(), backup_jpeg.size());
+    }
+
+    return icon;
+}
+
+void ConfigureSystem::PopulateUserList() {
+    const auto& profiles = profile_manager->GetAllUsers();
+    for (const auto& user : profiles) {
+        Service::Account::ProfileBase profile;
+        if (!profile_manager->GetProfileBase(user, profile))
+            continue;
+
+        const auto username = Common::StringFromFixedZeroTerminatedBuffer(
+            reinterpret_cast<const char*>(profile.username.data()), profile.username.size());
+
+        list_items.push_back(QList<QStandardItem*>{new QStandardItem{
+            GetIcon(user).scaled(64, 64, Qt::IgnoreAspectRatio, Qt::SmoothTransformation),
+            QString::fromStdString(username + '\n' + user.FormatSwitch())}});
+    }
+
+    for (const auto& item : list_items)
+        item_model->appendRow(item);
+}
+
+void ConfigureSystem::UpdateCurrentUser() {
+    ui->pm_add->setEnabled(profile_manager->GetUserCount() < Service::Account::MAX_USERS);
+
+    const auto& current_user = profile_manager->GetUser(Settings::values.current_user);
+    ASSERT(current_user != boost::none);
+    const auto username = GetAccountUsername(*current_user);
+
+    scene->clear();
+    scene->addPixmap(
+        GetIcon(*current_user).scaled(48, 48, Qt::IgnoreAspectRatio, Qt::SmoothTransformation));
+    ui->current_user_username->setText(QString::fromStdString(username));
 }
 
 void ConfigureSystem::ReadSystemSettings() {}
 
+std::string ConfigureSystem::GetAccountUsername(Service::Account::UUID uuid) const {
+    Service::Account::ProfileBase profile;
+    if (!profile_manager->GetProfileBase(uuid, profile))
+        return "";
+    return Common::StringFromFixedZeroTerminatedBuffer(
+        reinterpret_cast<const char*>(profile.username.data()), profile.username.size());
+}
+
 void ConfigureSystem::applyConfiguration() {
     if (!enabled)
         return;
-    Settings::values.username = ui->edit_username->text().toStdString();
+
     Settings::values.language_index = ui->combo_language->currentIndex();
     Settings::Apply();
 }
@@ -92,3 +219,130 @@ void ConfigureSystem::refreshConsoleID() {
     ui->label_console_id->setText(
         tr("Console ID: 0x%1").arg(QString::number(console_id, 16).toUpper()));
 }
+
+void ConfigureSystem::SelectUser(const QModelIndex& index) {
+    Settings::values.current_user =
+        std::clamp<std::size_t>(index.row(), 0, profile_manager->GetUserCount() - 1);
+
+    UpdateCurrentUser();
+
+    ui->pm_remove->setEnabled(profile_manager->GetUserCount() >= 2);
+    ui->pm_rename->setEnabled(true);
+    ui->pm_set_image->setEnabled(true);
+}
+
+void ConfigureSystem::AddUser() {
+    Service::Account::UUID uuid;
+    uuid.Generate();
+
+    bool ok = false;
+    const auto username =
+        QInputDialog::getText(this, tr("Enter Username"), tr("Enter a username for the new user:"),
+                              QLineEdit::Normal, QString(), &ok);
+    if (!ok)
+        return;
+
+    profile_manager->CreateNewUser(uuid, username.toStdString());
+
+    item_model->appendRow(new QStandardItem{
+        GetIcon(uuid).scaled(64, 64, Qt::IgnoreAspectRatio, Qt::SmoothTransformation),
+        QString::fromStdString(username.toStdString() + '\n' + uuid.FormatSwitch())});
+}
+
+void ConfigureSystem::RenameUser() {
+    const auto user = tree_view->currentIndex().row();
+    const auto uuid = profile_manager->GetUser(user);
+    ASSERT(uuid != boost::none);
+    const auto username = GetAccountUsername(*uuid);
+
+    Service::Account::ProfileBase profile;
+    if (!profile_manager->GetProfileBase(*uuid, profile))
+        return;
+
+    bool ok = false;
+    const auto new_username =
+        QInputDialog::getText(this, tr("Enter Username"), tr("Enter a new username:"),
+                              QLineEdit::Normal, QString::fromStdString(username), &ok);
+
+    if (!ok)
+        return;
+
+    std::fill(profile.username.begin(), profile.username.end(), '\0');
+    const auto username_std = new_username.toStdString();
+    if (username_std.size() > profile.username.size()) {
+        std::copy_n(username_std.begin(), std::min(profile.username.size(), username_std.size()),
+                    profile.username.begin());
+    } else {
+        std::copy(username_std.begin(), username_std.end(), profile.username.begin());
+    }
+
+    profile_manager->SetProfileBase(*uuid, profile);
+
+    item_model->setItem(
+        user, 0,
+        new QStandardItem{
+            GetIcon(*uuid).scaled(64, 64, Qt::IgnoreAspectRatio, Qt::SmoothTransformation),
+            tr("%1\n%2", "%1 is the profile username, %2 is the formatted UUID (e.g. "
+                         "00112233-4455-6677-8899-AABBCCDDEEFF))")
+                .arg(QString::fromStdString(username_std),
+                     QString::fromStdString(uuid->FormatSwitch()))});
+    UpdateCurrentUser();
+}
+
+void ConfigureSystem::DeleteUser() {
+    const auto index = tree_view->currentIndex().row();
+    const auto uuid = profile_manager->GetUser(index);
+    ASSERT(uuid != boost::none);
+    const auto username = GetAccountUsername(*uuid);
+
+    const auto confirm =
+        QMessageBox::question(this, tr("Confirm Delete"),
+                              tr("You are about to delete user with name %1. Are you sure?")
+                                  .arg(QString::fromStdString(username)));
+
+    if (confirm == QMessageBox::No)
+        return;
+
+    if (Settings::values.current_user == tree_view->currentIndex().row())
+        Settings::values.current_user = 0;
+    UpdateCurrentUser();
+
+    if (!profile_manager->RemoveUser(*uuid))
+        return;
+
+    item_model->removeRows(tree_view->currentIndex().row(), 1);
+    tree_view->clearSelection();
+
+    ui->pm_remove->setEnabled(false);
+    ui->pm_rename->setEnabled(false);
+}
+
+void ConfigureSystem::SetUserImage() {
+    const auto index = tree_view->currentIndex().row();
+    const auto uuid = profile_manager->GetUser(index);
+    ASSERT(uuid != boost::none);
+    const auto username = GetAccountUsername(*uuid);
+
+    const auto file = QFileDialog::getOpenFileName(this, tr("Select User Image"), QString(),
+                                                   "JPEG Images (*.jpg *.jpeg)");
+
+    if (file.isEmpty())
+        return;
+
+    FileUtil::Delete(GetImagePath(*uuid));
+
+    const auto raw_path =
+        FileUtil::GetUserPath(FileUtil::UserPath::NANDDir) + "/system/save/8000000000000010";
+    if (FileUtil::Exists(raw_path) && !FileUtil::IsDirectory(raw_path))
+        FileUtil::Delete(raw_path);
+
+    FileUtil::CreateFullPath(GetImagePath(*uuid));
+    FileUtil::Copy(file.toStdString(), GetImagePath(*uuid));
+
+    item_model->setItem(
+        index, 0,
+        new QStandardItem{
+            GetIcon(*uuid).scaled(64, 64, Qt::IgnoreAspectRatio, Qt::SmoothTransformation),
+            QString::fromStdString(username + '\n' + uuid->FormatSwitch())});
+    UpdateCurrentUser();
+}
diff --git a/src/yuzu/configuration/configure_system.h b/src/yuzu/configuration/configure_system.h
index f13de17d4..b73e0719c 100644
--- a/src/yuzu/configuration/configure_system.h
+++ b/src/yuzu/configuration/configure_system.h
@@ -5,8 +5,21 @@
 #pragma once
 
 #include <memory>
+
+#include <QList>
 #include <QWidget>
 
+namespace Service::Account {
+class ProfileManager;
+struct UUID;
+} // namespace Service::Account
+
+class QGraphicsScene;
+class QStandardItem;
+class QStandardItemModel;
+class QTreeView;
+class QVBoxLayout;
+
 namespace Ui {
 class ConfigureSystem;
 }
@@ -21,18 +34,36 @@ public:
     void applyConfiguration();
     void setConfiguration();
 
+    void PopulateUserList();
+    void UpdateCurrentUser();
+
 public slots:
     void updateBirthdayComboBox(int birthmonth_index);
     void refreshConsoleID();
 
+    void SelectUser(const QModelIndex& index);
+    void AddUser();
+    void RenameUser();
+    void DeleteUser();
+    void SetUserImage();
+
 private:
     void ReadSystemSettings();
+    std::string GetAccountUsername(Service::Account::UUID uuid) const;
+
+    QVBoxLayout* layout;
+    QTreeView* tree_view;
+    QStandardItemModel* item_model;
+    QGraphicsScene* scene;
+
+    std::vector<QList<QStandardItem*>> list_items;
 
     std::unique_ptr<Ui::ConfigureSystem> ui;
     bool enabled;
 
-    std::u16string username;
     int birthmonth, birthday;
     int language_index;
     int sound_index;
+
+    std::unique_ptr<Service::Account::ProfileManager> profile_manager;
 };
diff --git a/src/yuzu/configuration/configure_system.ui b/src/yuzu/configuration/configure_system.ui
index f3f8db038..020b32a37 100644
--- a/src/yuzu/configuration/configure_system.ui
+++ b/src/yuzu/configuration/configure_system.ui
@@ -7,7 +7,7 @@
     <x>0</x>
     <y>0</y>
     <width>360</width>
-    <height>377</height>
+    <height>483</height>
    </rect>
   </property>
   <property name="windowTitle">
@@ -22,34 +22,28 @@
         <string>System Settings</string>
        </property>
        <layout class="QGridLayout" name="gridLayout">
-        <item row="0" column="0">
-         <widget class="QLabel" name="label_username">
-          <property name="text">
-           <string>Username</string>
-          </property>
-         </widget>
-        </item>
-        <item row="0" column="1">
-         <widget class="QLineEdit" name="edit_username">
-          <property name="sizePolicy">
-           <sizepolicy hsizetype="Preferred" vsizetype="Fixed">
-            <horstretch>0</horstretch>
-            <verstretch>0</verstretch>
-           </sizepolicy>
-          </property>
-          <property name="maxLength">
-           <number>32</number>
-          </property>
-         </widget>
-        </item>
         <item row="1" column="0">
+         <widget class="QLabel" name="label_language">
+          <property name="text">
+           <string>Language</string>
+          </property>
+         </widget>
+        </item>
+        <item row="0" column="0">
          <widget class="QLabel" name="label_birthday">
           <property name="text">
            <string>Birthday</string>
           </property>
          </widget>
         </item>
-        <item row="1" column="1">
+        <item row="3" column="0">
+         <widget class="QLabel" name="label_console_id">
+          <property name="text">
+           <string>Console ID:</string>
+          </property>
+         </widget>
+        </item>
+        <item row="0" column="1">
          <layout class="QHBoxLayout" name="horizontalLayout_birthday2">
           <item>
            <widget class="QComboBox" name="combo_birthmonth">
@@ -120,14 +114,7 @@
           </item>
          </layout>
         </item>
-        <item row="2" column="0">
-         <widget class="QLabel" name="label_language">
-          <property name="text">
-           <string>Language</string>
-          </property>
-         </widget>
-        </item>
-        <item row="2" column="1">
+        <item row="1" column="1">
          <widget class="QComboBox" name="combo_language">
           <property name="toolTip">
            <string>Note: this can be overridden when region setting is auto-select</string>
@@ -187,31 +174,31 @@
             <string>Russian (Русский)</string>
            </property>
           </item>
-           <item>
-             <property name="text">
-               <string>Taiwanese</string>
-             </property>
-           </item>
-           <item>
-             <property name="text">
-               <string>British English</string>
-             </property>
-           </item>
-           <item>
-             <property name="text">
-               <string>Canadian French</string>
-             </property>
-           </item>
-           <item>
-             <property name="text">
-               <string>Latin American Spanish</string>
-             </property>
-           </item>
-           <item>
-             <property name="text">
-               <string>Simplified Chinese</string>
-             </property>
-           </item>
+          <item>
+           <property name="text">
+            <string>Taiwanese</string>
+           </property>
+          </item>
+          <item>
+           <property name="text">
+            <string>British English</string>
+           </property>
+          </item>
+          <item>
+           <property name="text">
+            <string>Canadian French</string>
+           </property>
+          </item>
+          <item>
+           <property name="text">
+            <string>Latin American Spanish</string>
+           </property>
+          </item>
+          <item>
+           <property name="text">
+            <string>Simplified Chinese</string>
+           </property>
+          </item>
           <item>
            <property name="text">
             <string>Traditional Chinese (正體中文)</string>
@@ -219,14 +206,14 @@
           </item>
          </widget>
         </item>
-        <item row="3" column="0">
+        <item row="2" column="0">
          <widget class="QLabel" name="label_sound">
           <property name="text">
            <string>Sound output mode</string>
           </property>
          </widget>
         </item>
-        <item row="3" column="1">
+        <item row="2" column="1">
          <widget class="QComboBox" name="combo_sound">
           <item>
            <property name="text">
@@ -245,14 +232,7 @@
           </item>
          </widget>
         </item>
-        <item row="4" column="0">
-         <widget class="QLabel" name="label_console_id">
-          <property name="text">
-           <string>Console ID:</string>
-          </property>
-         </widget>
-        </item>
-        <item row="4" column="1">
+        <item row="3" column="1">
          <widget class="QPushButton" name="button_regenerate_console_id">
           <property name="sizePolicy">
            <sizepolicy hsizetype="Fixed" vsizetype="Fixed">
@@ -271,6 +251,143 @@
        </layout>
       </widget>
      </item>
+     <item>
+      <widget class="QGroupBox" name="gridGroupBox">
+       <property name="title">
+        <string>Profile Manager</string>
+       </property>
+       <layout class="QGridLayout" name="gridLayout_2">
+        <property name="sizeConstraint">
+         <enum>QLayout::SetNoConstraint</enum>
+        </property>
+        <item row="0" column="0">
+         <layout class="QHBoxLayout" name="horizontalLayout_2">
+          <item>
+           <widget class="QLabel" name="label">
+            <property name="sizePolicy">
+             <sizepolicy hsizetype="Preferred" vsizetype="Minimum">
+              <horstretch>0</horstretch>
+              <verstretch>0</verstretch>
+             </sizepolicy>
+            </property>
+            <property name="text">
+             <string>Current User</string>
+            </property>
+           </widget>
+          </item>
+          <item>
+           <widget class="QGraphicsView" name="current_user_icon">
+            <property name="minimumSize">
+             <size>
+              <width>48</width>
+              <height>48</height>
+             </size>
+            </property>
+            <property name="maximumSize">
+             <size>
+              <width>48</width>
+              <height>48</height>
+             </size>
+            </property>
+            <property name="verticalScrollBarPolicy">
+             <enum>Qt::ScrollBarAlwaysOff</enum>
+            </property>
+            <property name="horizontalScrollBarPolicy">
+             <enum>Qt::ScrollBarAlwaysOff</enum>
+            </property>
+            <property name="interactive">
+             <bool>false</bool>
+            </property>
+           </widget>
+          </item>
+          <item>
+           <widget class="QLabel" name="current_user_username">
+            <property name="sizePolicy">
+             <sizepolicy hsizetype="Preferred" vsizetype="Minimum">
+              <horstretch>0</horstretch>
+              <verstretch>0</verstretch>
+             </sizepolicy>
+            </property>
+            <property name="text">
+             <string>Username</string>
+            </property>
+           </widget>
+          </item>
+         </layout>
+        </item>
+        <item row="1" column="0">
+         <widget class="QScrollArea" name="scrollArea">
+          <property name="sizePolicy">
+           <sizepolicy hsizetype="Expanding" vsizetype="Expanding">
+            <horstretch>0</horstretch>
+            <verstretch>0</verstretch>
+           </sizepolicy>
+          </property>
+          <property name="frameShape">
+           <enum>QFrame::StyledPanel</enum>
+          </property>
+          <property name="widgetResizable">
+           <bool>false</bool>
+          </property>
+         </widget>
+        </item>
+        <item row="2" column="0">
+         <layout class="QHBoxLayout" name="horizontalLayout_3">
+          <item>
+           <widget class="QPushButton" name="pm_set_image">
+            <property name="enabled">
+             <bool>false</bool>
+            </property>
+            <property name="text">
+             <string>Set Image</string>
+            </property>
+           </widget>
+          </item>
+          <item>
+           <spacer name="horizontalSpacer">
+            <property name="orientation">
+             <enum>Qt::Horizontal</enum>
+            </property>
+            <property name="sizeHint" stdset="0">
+             <size>
+              <width>40</width>
+              <height>20</height>
+             </size>
+            </property>
+           </spacer>
+          </item>
+          <item>
+           <widget class="QPushButton" name="pm_add">
+            <property name="text">
+             <string>Add</string>
+            </property>
+           </widget>
+          </item>
+          <item>
+           <widget class="QPushButton" name="pm_rename">
+            <property name="enabled">
+             <bool>false</bool>
+            </property>
+            <property name="text">
+             <string>Rename</string>
+            </property>
+           </widget>
+          </item>
+          <item>
+           <widget class="QPushButton" name="pm_remove">
+            <property name="enabled">
+             <bool>false</bool>
+            </property>
+            <property name="text">
+             <string>Remove</string>
+            </property>
+           </widget>
+          </item>
+         </layout>
+        </item>
+       </layout>
+      </widget>
+     </item>
      <item>
       <widget class="QLabel" name="label_disable_info">
        <property name="text">
@@ -281,19 +398,6 @@
        </property>
       </widget>
      </item>
-     <item>
-      <spacer name="verticalSpacer">
-       <property name="orientation">
-        <enum>Qt::Vertical</enum>
-       </property>
-       <property name="sizeHint" stdset="0">
-        <size>
-         <width>20</width>
-         <height>40</height>
-        </size>
-       </property>
-      </spacer>
-     </item>
     </layout>
    </item>
   </layout>
diff --git a/src/yuzu/main.cpp b/src/yuzu/main.cpp
index be9896614..47f494841 100644
--- a/src/yuzu/main.cpp
+++ b/src/yuzu/main.cpp
@@ -10,6 +10,7 @@
 // VFS includes must be before glad as they will conflict with Windows file api, which uses defines.
 #include "core/file_sys/vfs.h"
 #include "core/file_sys/vfs_real.h"
+#include "core/hle/service/acc/profile_manager.h"
 
 // These are wrappers to avoid the calls to CreateDirectory and CreateFile becuase of the Windows
 // defines.
@@ -757,12 +758,43 @@ void GMainWindow::OnGameListOpenFolder(u64 program_id, GameListOpenTarget target
         open_target = "Save Data";
         const std::string nand_dir = FileUtil::GetUserPath(FileUtil::UserPath::NANDDir);
         ASSERT(program_id != 0);
-        // TODO(tech4me): Update this to work with arbitrary user profile
-        // Refer to core/hle/service/acc/profile_manager.cpp ProfileManager constructor
-        constexpr u128 user_id = {1, 0};
+
+        Service::Account::ProfileManager manager{};
+        const auto user_ids = manager.GetAllUsers();
+        QStringList list;
+        for (const auto& user_id : user_ids) {
+            if (user_id == Service::Account::UUID{})
+                continue;
+            Service::Account::ProfileBase base;
+            if (!manager.GetProfileBase(user_id, base))
+                continue;
+
+            list.push_back(QString::fromStdString(Common::StringFromFixedZeroTerminatedBuffer(
+                reinterpret_cast<const char*>(base.username.data()), base.username.size())));
+        }
+
+        bool ok = false;
+        const auto index_string =
+            QInputDialog::getItem(this, tr("Select User"),
+                                  tr("Please select the user's save data you would like to open."),
+                                  list, Settings::values.current_user, false, &ok);
+        if (!ok)
+            return;
+
+        const auto index = list.indexOf(index_string);
+        ASSERT(index != -1 && index < 8);
+
+        const auto user_id = manager.GetUser(index);
+        ASSERT(user_id != boost::none);
         path = nand_dir + FileSys::SaveDataFactory::GetFullPath(FileSys::SaveDataSpaceId::NandUser,
                                                                 FileSys::SaveDataType::SaveData,
-                                                                program_id, user_id, 0);
+                                                                program_id, user_id->uuid, 0);
+
+        if (!FileUtil::Exists(path)) {
+            FileUtil::CreateFullPath(path);
+            FileUtil::CreateDir(path);
+        }
+
         break;
     }
     case GameListOpenTarget::ModData: {
diff --git a/src/yuzu_cmd/config.cpp b/src/yuzu_cmd/config.cpp
index 654a15a5c..b456266a6 100644
--- a/src/yuzu_cmd/config.cpp
+++ b/src/yuzu_cmd/config.cpp
@@ -8,6 +8,7 @@
 #include "common/file_util.h"
 #include "common/logging/log.h"
 #include "common/param_package.h"
+#include "core/hle/service/acc/profile_manager.h"
 #include "core/settings.h"
 #include "input_common/main.h"
 #include "yuzu_cmd/config.h"
@@ -126,10 +127,10 @@ void Config::ReadValues() {
     // System
     Settings::values.use_docked_mode = sdl2_config->GetBoolean("System", "use_docked_mode", false);
     Settings::values.enable_nfc = sdl2_config->GetBoolean("System", "enable_nfc", true);
-    Settings::values.username = sdl2_config->Get("System", "username", "yuzu");
-    if (Settings::values.username.empty()) {
-        Settings::values.username = "yuzu";
-    }
+    const auto size = sdl2_config->GetInteger("System", "users_size", 0);
+
+    Settings::values.current_user = std::clamp<int>(
+        sdl2_config->GetInteger("System", "current_user", 0), 0, Service::Account::MAX_USERS - 1);
 
     // Miscellaneous
     Settings::values.log_filter = sdl2_config->Get("Miscellaneous", "log_filter", "*:Trace");