diff --git a/CMakeLists.txt b/CMakeLists.txt
index 542fce810..90388bf09 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -684,3 +684,42 @@ if(ENABLE_QT AND UNIX AND NOT APPLE)
     install(FILES "dist/org.citron_emu.citron.metainfo.xml"
             DESTINATION "share/metainfo")
 endif()
+
+# PGO Configuration
+option(CITRON_ENABLE_PGO_INSTRUMENT "Enable Profile-Guided Optimization instrumentation build" OFF)
+option(CITRON_ENABLE_PGO_OPTIMIZE "Enable Profile-Guided Optimization optimization build" OFF)
+
+if(MSVC)
+    if(CITRON_ENABLE_PGO_INSTRUMENT)
+        string(APPEND CMAKE_CXX_FLAGS_RELEASE " /GL /LTCG:PGINSTRUMENT")
+        string(APPEND CMAKE_EXE_LINKER_FLAGS_RELEASE " /LTCG:PGINSTRUMENT")
+        string(APPEND CMAKE_SHARED_LINKER_FLAGS_RELEASE " /LTCG:PGINSTRUMENT")
+    elseif(CITRON_ENABLE_PGO_OPTIMIZE)
+        string(APPEND CMAKE_CXX_FLAGS_RELEASE " /GL /LTCG:PGOPTIMIZE")
+        string(APPEND CMAKE_EXE_LINKER_FLAGS_RELEASE " /LTCG:PGOPTIMIZE")
+        string(APPEND CMAKE_SHARED_LINKER_FLAGS_RELEASE " /LTCG:PGOPTIMIZE")
+    endif()
+else()
+    # GCC and Clang PGO flags
+    if(CITRON_ENABLE_PGO_INSTRUMENT)
+        if(CMAKE_CXX_COMPILER_ID MATCHES "Clang")
+            string(APPEND CMAKE_CXX_FLAGS_RELEASE " -fprofile-instr-generate")
+            string(APPEND CMAKE_EXE_LINKER_FLAGS_RELEASE " -fprofile-instr-generate")
+            string(APPEND CMAKE_SHARED_LINKER_FLAGS_RELEASE " -fprofile-instr-generate")
+        else() # GCC
+            string(APPEND CMAKE_CXX_FLAGS_RELEASE " -fprofile-generate")
+            string(APPEND CMAKE_EXE_LINKER_FLAGS_RELEASE " -fprofile-generate")
+            string(APPEND CMAKE_SHARED_LINKER_FLAGS_RELEASE " -fprofile-generate")
+        endif()
+    elseif(CITRON_ENABLE_PGO_OPTIMIZE)
+        if(CMAKE_CXX_COMPILER_ID MATCHES "Clang")
+            string(APPEND CMAKE_CXX_FLAGS_RELEASE " -fprofile-instr-use=default.profdata")
+            string(APPEND CMAKE_EXE_LINKER_FLAGS_RELEASE " -fprofile-instr-use=default.profdata")
+            string(APPEND CMAKE_SHARED_LINKER_FLAGS_RELEASE " -fprofile-instr-use=default.profdata")
+        else() # GCC
+            string(APPEND CMAKE_CXX_FLAGS_RELEASE " -fprofile-use")
+            string(APPEND CMAKE_EXE_LINKER_FLAGS_RELEASE " -fprofile-use")
+            string(APPEND CMAKE_SHARED_LINKER_FLAGS_RELEASE " -fprofile-use")
+        endif()
+    endif()
+endif()
diff --git a/externals/Vulkan-Headers b/externals/Vulkan-Headers
index 952f776f6..0f0cfd88d 160000
--- a/externals/Vulkan-Headers
+++ b/externals/Vulkan-Headers
@@ -1 +1 @@
-Subproject commit 952f776f6573aafbb62ea717d871cd1d6816c387
+Subproject commit 0f0cfd88d7e6ece3ca6456df692f0055bde94be7
diff --git a/externals/Vulkan-Utility-Libraries b/externals/Vulkan-Utility-Libraries
index 5f41f2a9b..50563f483 160000
--- a/externals/Vulkan-Utility-Libraries
+++ b/externals/Vulkan-Utility-Libraries
@@ -1 +1 @@
-Subproject commit 5f41f2a9bf3589dc5d1791d42ff46f1abe873f2b
+Subproject commit 50563f48368d75281bc2fb1c3407dc531ce28910
diff --git a/externals/vcpkg b/externals/vcpkg
index efb1e7436..cd1099f42 160000
--- a/externals/vcpkg
+++ b/externals/vcpkg
@@ -1 +1 @@
-Subproject commit efb1e7436979a30c4d3e5ab2375fd8e2e461d541
+Subproject commit cd1099f42a3c2ee28dc68e3db3f6f88658982736